Buckingham Institute for Translational Medicine
BITM is an internationally recognised research group with a track record in drug discovery, including beta3-adrenoceptor agonists for obesity, orexin and MCH-antagonists, and the insulin sensitiser drug rosiglitazone.
Our focus is encompassed by 3 research themes, which highlight our combined basic research, drug discovery and clinical expertise. The aim of our pre-clinical research is to inform drug development and enhance underlying biological understanding. As part of the University of Buckingham Medical School and our long-standing academic, clinical and pharmaceutical collaborations we are translating our key research themes into clinical studies and ultimately therapeutics.
The Buckingham Institute for Translational Medicine (BITM) is based within the Clore Laboratory. The Clore Lab was founded in 1986 by Professor Anne Beloff-Chain, wife of Nobel Laureate Sir Ernst Chain, with funds from the Clore Foundation. Initially multi-disciplined biology research including obesity/diabetes, plant cell culture and biology. In 1991, Professor Mike Cawthorne ran the research group on a part-time basis, and from 1994, He led BITM until his death in 2015. Mike orientated the Lab interests towards diabetes and obesity research with funds from industry and a private Foundations. He was awarded the 2001 Society for Medicines Research award for drug discovery in recognition of his work on the discovery of rosiglitazone.