Contract Research: Pre-clinical Evaluation Service

Pre-clinical evaluation of anti-obesity and anti-diabetic agents – a complete service by experts

Clore Laboratory, Buckingham Institute for Translational Medicine
The Clore Laboratory staff members are internationally recognised drug discovery experts and opinion leaders within the fields of obesity, diabetes and metabolic disease. The Clore Laboratory has a track record of successful pre-clinical and predictive evaluation of novel agents.

Areas of previous in vivo expertise

Animal model:
DIO mice and rats
ob/ob and db/db mice
fa/fa rats and ZDF rats
HFD/STZ mice
Hamsters

Acute and chronic studies including POC

Advice on study design

Measurements available:

  • food intake and food choice
  • energy expenditure and RQ
  • thermic response to food
  • basal metabolic rate at thermoneutrality
  • body composition in mice by NMR
  • metabolic parameters such as glucose, lactate, lipids
  • hormones such as insulin, glucagon, active and total GLP-1, and adipokines
  • glucose tolerance, insulin tolerance and pyruvate tolerance
  • euglycemic hyperinsulinemic clamps
  • hepatic glucose output and tissue glucose uptake rates
  • isolated pancreatic islets, hepatocytes and adipocytes
  • isolated soleus muscle
  • pancreatic islet cell mass
  • liver and muscle toxicology markers
  • real tie inflammatory markers
  • bioinformatics; automated imaging tools
  • cell culture
  • central administration
  • immunohistochemistry
  • microarrays, RNA analysis and Western blots

For confidential enquiries about services available and quotations please contact:

Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK

Dr Mohamed Zaibi
email: mohamed.zaibi@buckingham.ac.uk
Tel: +44 (0)1280 820370