Contract Research: Pre-clinical Evaluation Service

Pre-clinical evaluation of anti-obesity and anti-diabetic agents – a complete service by experts

Clore Laboratory, Buckingham Institute for Translational Medicine

The Clore Laboratory staff members are internationally recognised drug discovery experts and opinion leaders within the fields of obesity, diabetes and metabolic disease. The Clore Laboratory has a track record of successful pre-clinical and predictive evaluation of novel agents.

Advice on experimental design:

An image showing the effects of obesity on rats

  • On animal models: DIO mice and rats – ob/ob and db/db mice – fa/fa rats and ZDF rats – HFD/STZ mice
  • On output measurements:
  • energy expenditure and RQ
  • thermic response to food
  • basal metabolic rate at thermoneutrality
  • body composition in mice by DEXA or NMR
  • glucose tolerance, insulin tolerance and pyruvate tolerance
  • euglycemic hyperinsulinemic clamps
  • isolated hepatocytes and adipocytes
  • isolated soleus muscle

Services available

Animal and human cells under the microscope

  • animal and human primary cells and cell lines
  • systemic and central Inflammatory markers
  • Oxidative stress markers
  • metabolic parameters such as glucose, lactate, lipids
  • hormones such as insulin, glucagon, GLP-1, and adipokines
  • microarrays, RNA analysis and Western blots
  • hepatic glucose output and tissue glucose uptake
  • liver and muscle toxicology markers
  • images analysis

For confidential enquiries about services available and quotations please contact: 

Clore Laboratory, University of Buckingham, Buckingham MK18 1EG, UK
Dr Mohamed Zaibi
mohamed.zaibi@buckingham.ac.uk
+44 (0)1280 820370