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Phase 1 Lead
The Clore Laboratory
University of Buckingham
MK18 1EG, UK
Tel (office): +44 (0)1280 820244
Fax: +44 (0)1280 820135
A graduate of the University of Edinburgh, Dr Langlands studied Genetics before going on to gain a PhD from the Department of Haematology. This was followed by postdoctoral research at the Universities of Bristol, Pittsburgh and Cambridge before moving to Buckingham to establish a new Bioinformatics MSc curriculum. He has written numerous research papers and maintains an active research programme in the Clore Laboratory at Buckingham, covering molecular aspects of dermatological disease.
Dr Langlands is also the coordinator for the postgraduate medicine programmes and the director of medical school development for the University of Buckingham.
Dr Langlands is a member of the Society for Investigative Dermatology and sits on the advisory board of the Open Dermatology Journal.
- Cutaneous tumour biology
- Diabetic and ageing skin
- Bioinformatics and bioimaging
Undergraduate medicine: phase 1 lead, lead for the phase 1 module- tissues of the body
Topics for MSc/PhD supervision
Diabetic and ageing skin
Bioinformatics and Bioimaging
Maysson Al-Haj Ibrahim
Osman Sharif Osman
Ahmed Hasham Kayani
Peer Reviewed Publications (last 5 years and selected)
Osman OS, Selway JL, Harikumar PE, Stocker CJ, Wargent CJ, Cawthorne MA, Jassim S, Langlands K. A Novel Method to Assess Collagen Architecture in Skin. BMC Bioinformatics 14, 260. http://www.biomedcentral.com/content/pdf/1471-2105-14-260.pdf
Al-Habian A, Zaibi MS, Krause M, Selway JL, Wargent ET, Newsholme P, Cawthorne MA, Stocker CJ, Langlands K. Increasing insulin resistance correlates with cutaneous damage in murine models of obesity and diabetes. Manuscript submitted to American Journal of Pathology
Selway JL, Kurczab T, Kealey T and Langlands K. Toll-Like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. BMC Dermatology 13, 10. http://www.biomedcentral.com/content/pdf/1471-5945-13-10.pdf
Harikumar PE, Selway JL, Chu A, and Langlands K (2013). Collagen remodelling and peripheral immune cell recruitment characterises the cutaneous Langerhans Cell Histiocytosis (LCH) microenvironment. Manuscript accepted by Int J Derm doi:10.1111/ijd.12375
Osman OS, Selway JL, Kępczyńska MA, Stocker CJ, O’Dowd JF, Cawthorne MA, Arch JRS, Jassim S, and Langlands K (2013). A novel automated image analysis method for accurate adipocyte quantification. Adipocyte 2(3): p1-5 doi:10.4161/adip.24652
Al-Haj Ibrahim, M., Jassim, S., Cawthorne, M.A., Langlands, K (2012) A topology-based score for pathway enrichment. J Comp Biol 19: 563-573 doi:10.1089/cmb.2011.0182
Al-Haj Ibrahim M, Jassim S, Cawthorne MA, Langlands, K (2011). A pathway-based gene selection method provides accurate disease classification. The International Journal of Digital Society (IJDS) 2: 566-573 http://infonomics-society.org/IJDS/A%20Pathway_based%20Gene%20Selection%20Method%20Provides%20Accurate%20Disease%20Classification.pdf
McLellan AS, Kealey T, Langlands K (2006). An E-box in the Exon 1 promoter Regulates insulin-like growth factor-1 expression in differentiating muscle cells. AJP Cell Physiol 291: C300-307 doi:10.1152/ajpcell.00345.2005
Yang C-L, Kurczab T, Down G, Kealey T, Langlands K (2005). Gene expression profiling of the ageing rat vibrissa follicle. Br J Dermatol 153: 22-28 doi:10.1111/j.1365-2133.2005.06550.x
McLellan AS, Langlands K, Kealey T (2002). Exhaustive identification of a functional protein subfamily by virtual library screening. Mech Dev 119 Suppl 1: S285-91 doi:10.1016/S0925-4773(03)00130-8
Langlands K, Down GA, Kealey T (2000). Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res 60: 5929-5933 http://cancerres.aacrjournals.org/content/60/21/5929.full.pdf+html
Langlands K, Yin X, Anand G, Prochownik EV (1997). Differential affinities of Id proteins for tissue restricted basic-helix-loop-helix transcription factors. J Biol Chem 272: 19785- 19793 doi:10.1074/jbc.272.32.19785