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Plant derived PPAR activators described in Journal of Nutritional Biochemistry paper
21 October 2008
Studies by Claire Cornick and colleagues at the Clore Laboratory, University of Buckingham, UK, on guggul gum (Commiphora mukul) have identified a novel component, commipheric acid, as a PPAR α/γ activator with an EC50 of 0.26 mg/ml and 0.3 mg/ml respectively. Guggul lipid was shown to protect Lep(ob)/Lep(ob) mice from diabetes.
Both guggul lipid and commipheric acid promoted adipocyte differentiation of 3T3L1 pre-adipocytes. Commipheric acid had no effect on liver X receptor activation, unlike guggul lipid.
In in vivo studies in Lep(ob)/Lep(ob) mice, commipheric acid was ineffective but the ethyl ester lowered fasting blood glucose and plasma insulin and triglycerides.
The work was conducted in collaboration with scientists at Unilever Corporate Research, Colworth, Bedfordshire, UK, with funding from Unilever.
The full reference is:
Claire L. Cornick, Barbara H. Strongitharm, Gary Sassano, Christopher Rawlins, Andrew E. Mayes, Alison N Joseph, Jacqueline O’Dowd, Claire Stocker, Ed Wargent, Michael A. Cawthorne, A. Louise Brown, Jonathan R.S. Arch. Identification of a novel agonist of peroxisome proliferator-activated receptors α and γ that may contribute to the anti-diabetic activity of guggulipid in Lep(ob)/Lep(ob) mice. J Nutr Biochem. e-pub ahead of print 14 October 2008. doi:10.1016/j.jnutbio.2008.07.010.
Claire Cornick was supported by a BBSRC Research Studentship.