Clore Laboratory research highlighted in British Journal of Pharmacology commentary
15 October 2008
The recent paper by Robert Ngala and colleagues on muscle β-adrenoceptors has been highlighted by Roger Summers in a commentary in British Journal of Pharmacology. Summers notes that, although β-adrenoceptors are one of the most widely studied groups of G-protein coupled receptors, they continue to provide surprises and insights that have general relevance to pharmacology.
The paper from the Clore Laboratory provides an example of atypical interaction by an agonist to promote glucose uptake and palmitate oxidation. Summers comments that identification of these novel interactions of ligands with the G-protein coupled receptor is likely to have important consequences for future drug discovery.
The references are:
Ngala RA, O’Dowd J, Wang SJ, Agarwal A, Stocker C, Cawthorne MA, Arch JRS. Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β2-adrenoceptor mechanisms. Br J Pharmacol. 2008 Oct;155(3): 395-406; e-pub 16 June 2008. doi:10.1038/bjp.2008.244
Summers RJ. Atypical pharmacologies at β-adrenoceptors. Br J Pharmacol. 2008 Oct;155(3): 285-287; e-pub 21 July 2008. doi:10.1038/bjp.2008.293