Claire Stocker

Claire Stocker2Dr Claire Stocker

Post-doctoral Fellow

The Clore Laboratory
University of Buckingham
Hunter Street
Buckingham
MK18 1EG, UK
Tel (office): +44 (0)1280 820349
Tel (lab): +44 (0)1280 820323
Fax: +44 (0)1280 820135
Email:  claire.stocker@buckingham.ac.uk

Biography

Claire was awarded her BSc (Hons) Biochemistry from the University of Southampton and a PhD from Imperial College, London and has worked in the pharmaceutical industry for three years. She was awarded the IASO New Investigator Award in 2002 shortly after joining the School of Science and Medicine. Claire is the Deputy Chairman for the School Ethics Committee and the Research Officer for Buckingham Institute for Translational Medicine (Clore Laboratory). In the undergraduate Medical School she is the Student Support Lead and Phase 1 Module lead for Metabolism.

Claire’s main research focus is on the developmental origins of metabolic disease and potential maternal intervention strategies. Her current interests are the identification of the underlying molecular mechanisms in the regulation of energy balance both centrally and in adipose tissue. But she also has an interest in beta adrenoceptor function, insulin sensitivity in the skin and in the identification of novel metabolic targets including chemerin, AMPK and G-protein-coupled receptors. Claire holds professional membership of Developmental Origins of Health and Disease (DOHaD), European Association for the Study of Diabetes (EASD) and the Association for the Study of Obesity (UK) (ASO). She is on the Editorial board of Frontiers in Epigenomics and is currently the Lead Guest Editor Special Edition ‘Developmental Programming’ for the Journal of Obesity http://www.hindawi.com/journals/jobe/si/359067/cfp/

Topics for PhD supervision

Adipose tissue function
Central regulation of energy intake
Diabetic and ageing skin

Research Students

Amgad Al-Habian (DPhil)
Avigit Guha Roy (DPhil)
Malgosia Kępczyńska (DPhil)
Jwan Jaffe (DPhil)
Andrew Neves (MSc)
Adil Amin (Clinical MSc)

Selected Publications (last 5 years): A full list of Claire’s publications can be found on Google Scholar.

Kępczyńska MA, Wargent ET, Cawthorne MA, Arch JRS, O’Dowd JF, Stocker CJ (2013). Circulating levels of the cytokines IL10, IFNg and resistin in an obese mouse model of developmental programming. JDOHaD 4(6): 491-498 doi.org/10.1017/S2040174413000263

Osman, OS, Selway JL, Kępczyńska MA, Stocker CJ, O’Dowd JF, Cawthorne MA, Arch JRS, Jassim S, Langlands K (2013). A novel automated image analysis method for accurate adipocyte quantification. Adipocyte 2(3): 1 doi:10.4161/adip.24652

Ngala RA, O’Dowd JF, Stocker CJ, Cawthorne MA, Arch JR (2013). β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling. Naunyn Schmiedebergs Arch Pharmacol 386(9): 761 doi:10.1007/s00210-013-0860-5

Wargent ET, O’Dowd J, Zaibi M, Gao D, Bing C, Trayhurn P, Cawthorne M, Arch JR, Stocker CJ (2013). Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist, and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice. J Endocrinol 216(2): 157 doi:10.1530/JOE-12-0402

Bellahcene M, O’Dowd JF, Wargent ET, Zaibi MS, Hislop DC, Ngala RA, Smith DM, Cawthorne MA, Stocker CJ, Arch JR (2012). Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. Br J Nutr 109(10): 1755 doi:10.1017/S0007114512003923

Rkhzay-Jaf J, O’Dowd JF, Stocker CJ (2012). Maternal obesity and the fetal origins of the metabolic syndrome. Curr Cardiovasc Risk Rep 6(5): 487 doi:10.1007/s12170-012-0257-x

Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O’Dowd JF, Zaibi MS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR (2012). Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y. Int J Obes (Lond) 36(8): 1040 doi:10.1038/ijo.2011.226

Zaibi MS, Stocker CJ, O’Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJ, Smith DM, Arch JR (2010). Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids.  FEBS Lett 584(11): 2381 doi:10.1016/j.febslet.2010.04.027

Bozaoglu K*, Curran JE*, Stocker CJ*, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JB 2010.Chemerin, a novel adipokine in the regulation of angiogenesis. J Clin Endocrinol Metab 95(5): 2476-85. *Equal first author contribution. doi:10.1210/jc.2010-0042

Ngala RA, O’Dowd J, Wang SJ, Stocker C, Cawthorne MA, Arch JR (2009). ß2-Adrenoceptors and non-ß-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle: studies using knockout mice. Br J Pharmacol 158(7): 1676 doi:10.1111/j.1476-5381.2009.00472.x

Ngala RA, O’Dowd J, Wang SJ, Agarwal A, Stocker C, Cawthorne MA, Arch JR (2008).Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β2-adrenoceptor mechanisms. Br J Pharmacol 155(3): 395  doi: 10.1038/bjp.2008.244

 

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