The Clore Laboratory
University of Buckingham
MK18 1EG, UK
Tel (lab): 01280 820341
Fax: 01280 820135
Parvathy completed her BSc (Hons) Biotechnology from University of Westminster and her final year project involved the isolation of ATP dependent Clp protease from Finegoldia magna using bioinformatics and PCR techniques. She went on to complete her MSc in Molecular Genetics from University of Leicester. Her research project involved the analysis of various components involved in the regulation of Elongator complex phosphomodification in Saccharomyces cerevisiae.
Parvathy is currently working as a research assistant on the Langerhans Cell Histiocytosis project but also completing her PhD part-time.
- Investigating the pathogenesis and mechanisms underlying Langerhans Cell Histiocytosis (LCH). This involves transcriptomics, bioinformatics and molecular biology techniques.
- In addition she performs all routine and specialized histology duties including: processing, embedding, cutting (paraffin and frozen sections), staining (various special stains including H&E), immunohistochemistry and immunofluorescence.
Peer Reviewed Publications and Abstracts (last 5 years and selected)
Osman OS, Selway JL, Harikumar PE, Stocker CJ, Wargent CJ, Cawthorne MA, Jassim S, Langlands K. A Novel Method to Assess Collagen Architecture in Skin. Manuscript submitted to BMC Bioinformatics
Harikumar PE, Selway JL, Chu A, Langlands K (2013). Collagen remodelling and peripheral immune cell recruitment characterises the cutaneous Langerhans Cell Histiocytosis (LCH) microenvironment. Manuscript accepted by Int J Derm
Harikumar PE, Roy AG, Osman OS, Selway JL, Stocker CJ, Wargent ET, Langlands KL (2013). A systematic analysis of extracellular matrix (ECM) changes in ageing skin. Int J Exp Pathol 94: A3-4
Selway JL, Harikumar PE, Yeo GSH, Chu A, Langlands K (2013). Transcriptional profiling demonstrates novel therapeutic targets in Langerhans Cell Histiocytosis. J Invest Dermatol 133(S1) S139
Harikumar PE, Selway JL, Chu A, Langlands K (2013). A comparative study of Langerhans Cell Histiocytosis (LCH) and non-melanoma skin cancer transcriptional profiles. J Invest Dermatol 133(S1) S69
Selway JL, Danapat S, Harikumar PE, Chu A and Langlands K. (2012) Epidermal growth factor signalling in the pathogenesis of Langerhans cell histiocytosis. Brit J Dermatol 166: 33
Selway JL, Seldon PM, Harikumar PE, Langlands K, Chu AC (2011). Differentially expressed genes identified in patients with Langerhans Cell Histiocytosis. J Invest Dermatol 131: S1, 15.