Mohamed Sghaier Zaibi

Dr Mohamed4Q1A3901 Sghaier Zaibi

Post-doctoral Fellow

The Clore Laboratory
University of Buckingham
Hunter Street
Buckingham
MK18 1EG, UK
Tel (office):  +44 (0)1280 820370
Tel (lab):  +44 (0)1280 820237
Email:  mohamed.zaibi@buckingham.ac.uk

Biography

Mohamed was awarded his BSc Biochemistry and his MSc Nutrition and Human Physiology from the School of Sciences and his PhD from Medical School, (University of Burgundy, France) where he worked on the effect of metformin (oral anti diabetic drug) on hepatic protein metabolism regulation.

Mohamed joined the Clore laboratory in 2005 to bring his extensive experience in metabolic diseases acquired at Dospharm Biotech Company and the European Centre of Bioprospectives (Normandy, France) where he was managing collaborative research  with Lipha-Merck, Air Liquid Sante  and  Beaufour-IPSEN on the investigation of novel drugs for the treatment of degenerative  diseases such as Alzheimer’s and diabetes.

Mohamed is a Research Fellow in Metabolic Diseases, in the Institute of Translational Medicine based in the Clore Laboratory at the University of Buckingham, He’s conducting the  in vivo and in vitro collaborative research in obesity and type 2 diabetes with our academic and pharmaceuticals companies partners.

Main research interests

  • Plant treatments for syndrome X (metabolic syndrome), obesity and diabetes
  • Regulation of islet cell proliferation
  • Thermogenesis stimulation in muscle and adipose tissue
  • Inflammation, angiogenesis and adipose tissue expansion
  • Regulation of hepatic and adipose cells metabolism

Teaching Experience

Lecturer in biology applied to human health and nutrition
College Superieur Saint Anselme, 27300 Bernay, Normandy, France

Part time lecturer in cell biology
University of Rouen, France

Part-time lecturer in  physiology
GRETA Val de Saone, Franche Comte. France

Postgraduate instructor in analytical Biochemistry methods
Faculty of Pharmacy, University of Burgundy, France

Selected Publications (last 5 years)

Al-Habian A, Zaibi MS, da Silva Krause M, Selway JL, Wargent ET, Newsholme P, Cawthorne MA, Stocker CJ, Langlands K. Increasing insulin resistance correlates with cutaneous damage in murine models of obesity and diabetes.  Submitted to American Journal of Pathology, December 2013.

Wargent ET, Zaibi MS, Silvestri C, Hislop DC, Stocker CJ, Stott CG, Guy GW, Duncan M, Di Marzo V, Cawthorne MA (2013). The cannabinoid delta-9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity.  Nutr Diabetes 3 e68 doi:10.1038/nutd.2013.9

Christiansen E, Hansen SVF, Urban C, Hudson B, Wargent ET, Grundmann M, Jenkins L, Zaibi M, Stocker CJ, Ullrich S, Kostenis E, Kassack MU, Milligan G, Cawthorne MA, Ulven T (2013). Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes. ACS Med Chem Lett 4(5): 441-445 doi:10.1021/ml4000673                     

Christiansen E, Due-Hansen ME, Urban C, Grundmann M, Schmidt J, Hansen SV, Hudson BD, Zaibi M, Markussen SB, Hagesaether E, Milligan G, Cawthorne MA, Kostenis E, Kassack MU, Ulven T (2013). Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability. J Med Chem 56(3): 982-92 doi:10.1021/jm301470a                                  

Wargent ET, O’Dowd JF, Zaibi MS, Gao D, Bing C, Trayhurn P, Cawthorne MA, Arch JR, Stocker CJ (2013). Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice.   J Endocrinol 216(2): 157-68 doi:10.1530/JOE-12-0402 

Bellahcene M, O’Dowd JF, Wargent ET, Zaibi MS, Hislop DC, Ngala RA, Smith DM, Cawthorne MA, Stocker CJ, Arch JR (2012). Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content.  Br J Nutr 109(10): 1755-64 doi:10.1017/S0007114512003923

Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O’Dowd JF, Zaibi MS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR (2012). Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y. Int J Obes 36(8): 1040-6 doi:10.1038/ijo.2011.226 

Zaibi MS, Stocker CJ, O’Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJH, Smith DM, Arch JRS (2010). Roles of GPR41 and GPR43 in leptin secretory responses of murin adipocytes to short chain fatty acids. FEBS Lett 384(11): 2381–2386 doi:10.1016/j.febslet.2010.04.027

Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HHH, Moses EK, Walder K, Cawthorne MA, Blangero J, Jowett JBM (2010). Chemerin, a Novel Adipokine in the Regulation of Angiogenesis.  J Clin Endocrinol Metab 95(5): 2476-2485 doi:10.1210/jc.2010-0042     

Selected Published Abstracts (last 5 years and selected)

Zaibi MS, Wargent ET, Stocker CJ, Hislop D, Duncan M, Stott C, Arch J RS, Cawthorne MA.  Anti-obesity, anti-diabetic and anti-inflammatory effects of tetrahydrocannabivarin (THCV) in high fat diet-induced obese C57Bl/6 female mice. 19th European Congress on Obesity (ECO 2012). 9-12 May 2012. Lyon, France.

Cawthorne MA, Wargent E, Zaibi MS, Stocker C, O’Dowd J, Harikumar P, Hislop D, Panchal R, Stott C, Duncan M, Guy GW.  Metabolic effects of non-psychoactive cannabinoids in animal models. World Diabetes Congress. 4-8 December 2011.  Dubai (UAE).

Zaibi MS, Al-Habian A, Stocker CJ, Langlands K.  Skin from obese (Lepob/Lepob) mice shows compromised dermal fibroblast physiology and disorganised collagen structure. 18th European Congress on Obesity (ECO 2011). 25-28 May 2011. Istanbul, Turkey.

Al-Habian A, Zaibi MS, Stocker CJ, Kępczyńska M, Wargent ET, Cawthorne MA, Langlands K.  Increasing insulin resistance correlates with progressive skin damage in murine models of obesity and diabetes. 71st Annual Meeting of the Society for Investigative Dermatology (SID).  4-7 May 2011. Phoenix, Arizona, USA.

Zaibi MS, Stocker CJ, O’Dowd J, Davies A, Bellhacene M, Cawthorne MA, Brown AJH, Smith DM, Arch JRS. Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids (SCFA). Keystone Symposia on molecular and cellular biology. 24-29 January 2010. Keystone, Colorado, USA.

Bozaoglu K, Curran JE, Stocker CJ, Zaibi MS, Segal D, Konstantopoulos N, Morrison S, Carless M, Dyer TD, Cole SA, Goring HHH, Moses EK, Walder K, Cawthorne M, Blangero J, Jowett JBM. The new adipokine chemerin is genetically regulated and promotes angiogenesis. 11th International Congress on Obesity. 11-15 July 2010. Stockholm, Sweden.

Kepczynska MA, O’Dowd JF, Wargent ET, Zaibi MS, Cawthorne MA, Arch JRS, Stocker CJ. Maternal fat feeding during both the peri-conceptional and gestational period in the mouse. Effects on the later health on her offspring. 2nd International Brussels Symposium on Pancreatic Islet Research. 18-21 June 2009. Brussels, Belgium.

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