Deputy Director of Metabolic Research
The Clore Laboratory
University of Buckingham
Tel: +44 (0)1280 820306
Fax: +44 (0)1280 820135
Jon is Deputy Director of Metabolic Research for the Buckingham Institute for Translational Medicine (the Clore Laboratory).
Jon worked in drug discovery in the pharmaceutical industry for the majority of his career, moving to Buckingham in 2001. He maintained a connection with the pharmaceutical industry through various consultancies and membership of scientific advisory boards. He has also been a governor (director) of a nutrition institute and a member of scientific advisory panels for two European Union research consortia.
Jon’s long-standing interest has been in the regulation of energy expenditure in relation to the cause and treatment of obesity and type 2 diabetes, but he has also published on the regulation of energy intake by the central nervous system, and other aspects of the regulation of energy balance and insulin sensitivity. Whilst most of his career has focused in metabolic disease, he spent six years working on novel bronchodilators for asthma.
A full list of Jon’s publications can be found on Google Scholar at:
Jon has an h index of 49 (29 since 2008), which is the number of his publications that have been cited at least that number of times.
Some of his most cited or recent publications are:
Arch, JR and Trayhurn, P (2013) Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification. Front Physiol 8;4: 64 doi:10.3389/fphys.2013.00064
Ngala RA, O’Dowd JF, Stocker CJ, Cawthorne MA, Arch JRS (2013) β2-adrenoceptor agonists can both stimulate and inhibit glucose uptake in mouse soleus muscle through ligand-directed signalling. Naunyn-Schmiedeberg’s Archives of Pharmacology, in press doi:10.1007/s00210-013-0860-5
Stocker CJ, Wargent ET, Martin-Gronert MS, Cripps RL, O’Dowd JF, Zaibi MS, Cottrell EC, Mercer JG, Duncan JS, Cawthorne MA, Ozanne SE, Arch JR (2012) Leanness in postnatally nutritionally programmed rats is associated with increased sensitivity to leptin and a melanocortin receptor agonist and decreased sensitivity to neuropeptide Y. Int J Obes 36:1040-6 doi:10.1038/ijo.2011.226
Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E (2011) A guide to analysis of mouse energy metabolism. Nature Methods 9: 57-63 doi:10.1038/nmeth.1806
Arch, JRS (2011) Thermogenesis and related metabolic targets in anti-diabetic therapy. Handb Exp Pharmacol 203: 201-255 doi:10.1007/978-3-642-17214-4_10
Zaibi MS, Stocker CJ, O’Dowd J, Davies A, Bellahcene M, Cawthorne MA, Brown AJ, Smith DM, Arch JR (2010) Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. FEBS Lett 584(11):2381-6 doi:10.1016/j.febslet.2010.04.027
Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A (2000) Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean. Nature 406, (6794), 415-8 doi:10.1038/35019082
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors – a family of hypothalamic neuropeptides and G-protein coupled receptors that regulate feeding behaviour. Cell 92, (4), 573-585 doi:10.1016/S0092-8674(00)80949-6
Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thody VE, Wilson C, Wilson S (1984) Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 309, 163-165 doi:10.1038/309163a0