The Clore Laboratory
University of Buckingham
MK18 1EG, UK
Tel (office): 01280 820240/820242
Fax: 01280 820135
Degrees: BSc (Reading), DPhil, DSc (Oxon). Paul Trayhurn formally joined the University as Dean of Research Strategy (part-time) in August 2011, having been associated with the Clore Laboratory as an Honorary Professor since 2009.
His previous appointments include: NATO European Research Fellowship in Strasbourg, France; Scientific/Senior Staff, MRC Dunn Nutrition Laboratory, Cambridge; Professor and Heritage Scholar in Nutrition & Metabolism, University of Alberta, Canada; Head of the Division of Biomedical Science, Rowett Research Institute, Aberdeen (Honorary Professor, University of Aberdeen); Professor of Nutritional Biology, University of Oslo, Norway. He was appointed to the Chair of Nutritional Biology at the University of Liverpool in 2001 and was Director of the Obesity Biology Unit; he is now an Emeritus Professor at Liverpool and an Honorary Professor in the University of Sydney Medical School.
Paul Trayhurn is a Fellow of the Royal Society of Edinburgh. He won the international André Mayer Prize in 1983 (given for outstanding work in the field of obesity for an investigator aged under 40), the Friedrich Wasserman Award in 2008 from the European Association for the Study of Obesity (for lifetime contributions to obesity research), and the Kaufmann Memorial Lecture Award in 2009 from the International Society for Fat Research. He is Chairman of both the Scientific and Awards Committees of the International Association for the Study of Obesity; he has also been a member of the BBSRC Agri-Food Committee and the MRC Population & Systems Medicine Board, and is a former Editor-in-Chief of the British Journal of Nutrition. His current external activities include membership of the Research Board (Biological Sciences) of the Royal Society and of the Research Committee of Diabetes UK, and he is a Trustee of the Nutrition Society. He is the author of 300 peer-reviewed publications on energy metabolism, obesity and adipose tissue function; his published work has received >13,500 citations.
- Energy balance and obesity – thermogenesis
- Adipose tissue biology, particularly: (i) adipose tissue as a secretory and endocrine organ, (ii) role of hypoxia in modulating adipose tissue function, (iii) adipose tissue both as a vitamin D target and storage site
Peer Reviewed Publications (selected)
Trayhurn P, Thurlby PL, James WPT (1977). Thermogenic defect in pre-obese ob/ob mice. Nature 266: 60-62 doi:10.1038/266060a0
Brooks SL, Rothwell NJ, Stock MJ, Goodbody AE, Trayhurn P (1980). Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 286: 274-276 doi:10.1038/286274a0
Trayhurn P, Jones PM, McGuckin MM, Goodbody AE (1982). Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice. Nature 295: 323-325 doi:10.1038/295323a0
Trayhurn P, Douglas JB, McGuckin MM (1982). Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice. Nature 298: 59-60 doi:10.1038/289699a0
Géloën A, Trayhurn P (1990). Regulation of the level of uncoupling protein in brown adipose tissue by insulin. Am J Physiol 258: R418-R424
Trayhurn P, Duncan JS, Rayner DV (1995). Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J 311: 729-733
Beattie JH, Wood AM, Newman AM, Bremner I, Choo KHA, Michalska AE, Duncan JS, Trayhurn P (1998). Hyperleptinaemia and obesity in metallothionein (-I and -II) null mice. Proc Natl Acad Sci USA 95: 358-363 dx.doi.org/10.1073/pnas.95.1.358
Trayhurn P, Wood IS (2004). Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355 dx.doi.org/10.1079/BJN20041213
Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, Cinti S, Tisdale MJ, Trayhurn P (2004). Zinc-a2-glycoprotein, a lipid mobilising factor, is expressed in adipocytes and upregulated in mice with cancer cachexia. Proc Natl Acad Sci USA 101: 2500-2505 http://dx.doi.org/10.1016/j.febslet.2004.11.042
Wang B, Wood IS, Trayhurn P (2007). Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflügers Archiv Eur J Physiol 455: 479-492 dx.doi.org/10.1007/s00424-007-0301-8
O’Hara A, Lim F-L, Mazzatti DJ, Trayhurn P (2009). Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is upregulated in human adipocytes by macrophage-conditioned medium. Pflügers Archiv Eur J Physiol 458: 1103-1114 doi: 10.1007/s00424-009-0693-8
Trayhurn P (2013). Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 93: 1-21 doi:10.1152/physrev.00017.2012