The Clore Laboratory
University of Buckingham
MK18 1EG, UK
Tel (Secretary): 01280 820242
Degrees: BSc (Reading), DPhil, DSc (Oxon). Paul Trayhurn formally joined the University as Dean of Research Strategy (part-time) 2011-14, having been associated with the Clore Laboratory as an Honorary Professor since 2009. He was Acting Director of the Clore from 2015 to 2017.
His previous appointments include: NATO European Research Fellowship in Strasbourg, France; Scientific/Senior Staff, MRC Dunn Nutrition Laboratory, Cambridge; Professor and Heritage Scholar in Nutrition & Metabolism, University of Alberta, Canada; Head of the Division of Biomedical Science, Rowett Research Institute, Aberdeen (Honorary Professor, University of Aberdeen); Professor of Nutritional Biology, University of Oslo, Norway. He was appointed to the Chair of Nutritional Biology at the University of Liverpool in 2001 and was Director of the Obesity Biology Unit; he is now an Emeritus Professor at Liverpool. He has held Honorary or Visiting Professorships at several institutions, including the University of Sydney and the University of the Highlands & Islands. From 2014-16, he held a Distinguished Scientist Fellowship at King Saud University, Saudi Arabia.
Paul Trayhurn was elected a Fellow of the Royal Society of Edinburgh in 1997. He won the international André Mayer Prize in 1983 (given for outstanding work in the field of obesity for an investigator aged under 40), the Friedrich Wasserman Award in 2008 from the European Association for the Study of Obesity (for lifetime contributions to obesity research), the Kaufmann Memorial Lecture Award in 2009 (from the International Society for Fat Research), and in 2019 received the inaugural Gowland Hopkins Award from the Nutrition Society (for ‘outstanding lifetime contributions to Cellular and Molecular Nutrition’). He has been Chairman of both the Scientific and Awards Committees of the International Association for the Study of Obesity; he has also been a member of the BBSRC Agri-Food Committee and the MRC Population & Systems Medicine Board, and is a former Editor-in-Chief of the British Journal of Nutrition and a Trustee of the Nutrition Society. His current activities include membership of the Newton Advanced Fellowships Panel of the Royal Society. He is the author of >300 peer-reviewed publications on energy metabolism, obesity and adipose tissue function; his published work has received >20,000 citations.
- Energy balance and obesity – brown adipose tissue thermogenesis
- Adipose tissue biology, particularly: (i) adipose tissue as a secretory and endocrine organ, (ii) role of hypoxia in modulating adipose tissue function
Peer Reviewed Publications (selected)
Trayhurn P, Thurlby PL, James WPT (1977). Thermogenic defect in pre-obese ob/ob mice. Nature 266: 60-62 doi:10.1038/266060a0
Brooks SL, Rothwell NJ, Stock MJ, Goodbody AE, Trayhurn P (1980). Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis. Nature 286: 274-276 doi:10.1038/286274a0
Trayhurn P, Jones PM, McGuckin MM, Goodbody AE (1982). Effects of overfeeding on energy balance and brown fat thermogenesis in obese (ob/ob) mice. Nature 295: 323-325 doi:10.1038/295323a0
Trayhurn P, Douglas JB, McGuckin MM (1982). Brown adipose tissue thermogenesis is ‘suppressed’ during lactation in mice. Nature 298: 59-60 doi:10.1038/289699a0
Beattie JH, Wood AM, Newman AM, Bremner I, Choo KHA, Michalska AE, Duncan JS, Trayhurn P (1998). Hyperleptinaemia and obesity in metallothionein (-I and -II) null mice. Proc Natl Acad Sci USA 95: 358-363 dx.doi.org/10.1073/pnas.95.1.358
Trayhurn P, Wood IS (2004). Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92: 347-355 dx.doi.org/10.1079/BJN20041213
Bing C, Bao Y, Jenkins J, Sanders P, Manieri M, Cinti S, Tisdale MJ, Trayhurn P (2004). Zinc-a2-glycoprotein, a lipid mobilising factor, is expressed in adipocytes and upregulated in mice with cancer cachexia. Proc Natl Acad Sci USA 101: 2500-2505 http://dx.doi.org/10.1016/j.febslet.2004.11.042
Trayhurn P (2013). Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 93: 1-21 doi:10.1152/physrev.00017.2012