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The Clore Laboratory
University of Buckingham
MK18 1EG, UK
Tel (office): +44 (0)1280 820184
Tel (lab): +44 (0)1280 820341
Fax: +44 (0)1280 820135
Joanne completed her BSc (Hons) Biochemistry from the University of Bath in 2006. This included a year working at the Merck, Sharpe and Dohme neuroscience research centre in Harlow, UK within the Alzheimer’s assay development laboratory.
Joanne completed her PhD entitled “GLP-1 and muscarinic receptor mediated activation of ERK1/2 in pancreatic β-cells” in the department of Cell Physiology and Pharmacology at the University of Leicester, UK in 2010.
Joanne’s experience in β-cell signalling allows her to contribute to the core diabetes research within the Clore lab in addition to her main research focuses, described below.
- Investigating the pathogenesis and mechanisms underlying Langerhans Cell Histiocytosis (LCH). This involves transcriptomics and molecular biology techniques whilst also utilising skills developed during her PhD with confocal microscopy.
- Histological, cellular and molecular assessment of diabetic and ageing skin
- The development and implementation of novel bioimaging techniques, specifically for cutaneous and endocrinology research.
Undergraduate medicine, phase 1: lead for membranes and receptors
Topics for MSc/PhD supervision:
Langerhans Cell Histiocytosis
Diabetic and ageing skin
Current Research Students
Osman Sharif Osman
Ahmed Hasham Kayani
Peer Reviewed Publications (last 5 years and selected)
Al-Habian A, Zaibi MS, Krause M, Selway JL, Wargent ET, Newsholme P, Cawthorne MA, Stocker CJ, Langlands K. “Increasing Insulin Resistance Correlates with Cutaneous Damage in Murine Models of Obesity and Diabetes”. Manuscript submitted to Am J Pathol
Harikumar PE, Selway JL, Chu A, Langlands K (2013). Collagen remodelling and peripheral immune cell recruitment characterises the cutaneous Langerhans Cell Histiocytosis (LCH) microenvironment. Manuscript accepted by Int J Derm
Selway JL, Kurczab T, Kealey T, Langlands K (2013). Toll-Like receptor 2 activation and comedogenesis: implications for the pathogenesis of acne. BMC Dermatol 13: 10 doi:10.1186/1471-5945-13-10
Osman OS, Selway JL, Harikumar PE, Stocker CJ, Wargent CJ, Cawthorne MA, Jassim S, Langlands K (2013). A Novel Method to Assess Collagen Architecture in Skin. BMC Bioinformatics 14: 260 doi:10.1186/1471-2105-14-260
Osman OS, Selway JL, Kępczyńska MA, Stocker CJ, O’Dowd JF, Cawthorne MA, Arch JRS, Jassim S, Langlands K (2013. A novel automated image analysis method for accurate adipocyte quantification. Adipocyte 2(3): 1-5 doi:10.4161/adip.24652
Selway JL, Moore CE, Mistry R, Challiss RAJ, Herbert TP (2012). Molecular mechanisms of muscarinic acetylcholine receptor–stimulated increase in cytosolic free Ca2+ concentration and ERK1/2 activation in the MIN6 pancreatic β-cell line. Acta Diabetol 49(4): 277–289 doi:10.1007/s00592-011-0314-9
Selway JL, Rigatti R, Storey N, Lu J, Willars GB, Herbert TP (2012). Evidence that Ca2+ within the microdomain of the L-Type voltage gated Ca2+ channel activates ERK in MIN6 cells in response to glucagon-like peptide-1. PLoS ONE 7(3): e33004. doi:10.1371/journal.pone.0033004
Selected Published Abstracts (last 5 years and selected)
Selway JL, Harikumar PE, Roy AG, Chu A, Langlands K (2013). Interaction of microRNA and gene expression networks in the pathogenesis of Langerhans Cell Histiocytosis (LCH). Proceedings of the Histiocyte Society Meeting, London 2012, to be published in Pediatric Blood and Cancer.
Selway JL, Harikumar PE, Yeo GSH, Chu A, Langlands K (2013). Transcriptional profiling demonstrates novel therapeutic targets in Langerhans Cell Histiocytosis. J Invest Dermatol 133(S1): S139
Harikumar PE, Selway JL, Chu A, Langlands K (2013). A comparative study of Langerhans Cell Histiocytosis (LCH) and non-melanoma skin cancer transcriptional profiles. J Invest Dermatol 133(S1): S69
Selway JL, Osman OS, Kępczyńska MA, Al-Habian A, Ditommaso T, Smyth I, Lelliott C, White J, Melvin D, The Sanger Mouse Genetics Project, Jassim S, Langlands K (2013). A novel automated image analysis method for rapidly segmenting and quantifying cutaneous features: Identification of genotypes with clinical features. J Invest Dermatol, 2013. 133(S1): S142
Harikumar PE, Roy AG, Osman OS, Selway JL, Stocker CJ, Wargent ET, Langlands KL (2013). A systematic analysis of extracellular matrix (ECM) changes in ageing skin. Int J Exp Pathol 94: A3-4
Rahman M, Selway JL, Herath D, Hazan A, Roy AG, Langlands K, Edmunds S, Kelsell D, Harwood C, Philpott MP, Neill GW (2013). Gene expression profiling demonstrates that the effects of PTCH1 suppression are not fully reversed upon pharmacological inhibition of SMOOTHENED in human keratinocytes. J Invest Dermatol 133(S1) S68
Roy AG, Selway JL, Langlands K, Stocker CJ, Cawthorne M (2012). Mitochondrial and extracellular matrix dysfunction characterized an in vitro model of ageing primary human dermal fibroblasts. Br J Dermatol 166: 30-31
Rahman M, Herath D, Selway JL, Roy AG, Nadendla S, Kelsell D, Harwood C, Philpott M, Neill G (2012). In vitro modelling of basal cell carcinoma reveals a novel PTCH1–GLI1 signalling axis that is unresponsive to Smoothened inhibitors in human keratinocytes. Br J Dermatol 166: 2