Many of our teaching academics are also “research active” and participate in industry-renowned research and publication outside of the University’s specialist centres. This may be in the form of collaborations with partner institutions or fellow academics, independent works, or particpating in large research groups.
Our academics are known for their contributions to the various canons of their specialisms, and are often invited to be key notes speakers at conferences around the world.
To read more about the research activities of Buckingham’s staff, please visit our Staff Directory to view our academics and their work.
- Clore Laboratory
- 6 February 2012
Paul Trayhurn et al., “Stimulation of inflammatory gene expression in human preadipocytes by macrophage-conditioned medium: Upregulation of IL-6 production by macrophage-derived IL-1β”
This study, which involved a key collaboration with Unilever, examined the effects of immune cells (macrophages) on other types of cells in the body’s fat (adipose) tissue. Read more >
- Clore Laboratory
- 22 January 2012
Hanna Tuomisto & Avijit Roy, “Could lab-grown meat soon be the solution to the world’s food crisis?”
Cultured meat, developed in the laboratory, could have a dramatic effect on global hunger and climate change
Read more >
- Clore Laboratory
- 28 November 2011
Kieron Rooney & Paul Trayhurn, “Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise”
This article considers the recently described functions of lactic acid, or lactate, which is well-known as an end-product of the breakdown of glucose by cells in the body. Read more >
- Clore Laboratory
- 3 October 2011
John Clapham & Jon Arch, “Targeting thermogenesis and related pathways in anti-obesity drug discovery”
There are two broad pharmacological approaches that can be applied in obesity drug discovery: reduce intake or absorption, or increase expenditure of calories (thermogenesis). This review looks at the latter approach. Read more >
- Clore Laboratory
- 8 August 2011
Jon Arch, “Thermogenesis and related metabolic targets in anti-diabetic therapy”
Exercise, together with a low-energy diet, is the first-line treatment for type 2 diabetes . Exercise improves insulin sensitivity by increasing the number or function of muscle mitochondria, structures within cells in which aerobic metabolism (the combustion of carbohydrate and fat to C02 and water) takes place. Read more >
- Clore Laboratory
- 28 July 2011
R.A. Ngala et al., “A new, highly selective murine peroxisome proliferator-activated receptor δ agonist…”
Ngala R.A., C.J. Stocker, A.G. Roy, D. Hislop, E. Wargent, R. Bell, D.G. Hassall, J.D. Harling, A.N. Billin, T.M. Willson, J.R. Arch, M.A. Cawthorne, “A new, highly selective murine peroxisome proliferator-activated receptor δ agonist increases responsiveness to thermogenic stimuli and … Read more >
- Clore Laboratory
- 28 June 2010
M.S. Zaibi et al., “Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids”
GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)-stimulated leptin secretion by activating Galpha(i). Read more >
- Clore Laboratory
- 28 December 2009
R.A. Ngala et al., “Beta2-adrenoceptors and non-beta-adrenoceptors mediate effects of BRL37344 and clenbuterol on glucose uptake in soleus muscle…”
In previous work, 10 pM BRL37344 and 10 pM clenbuterol stimulated glucose uptake in mouse soleus muscle. Ten nM BRL37344 also stimulated uptake but 100 nM clenbuterol inhibited uptake. Read more >
- Clore Laboratory
- 28 October 2009
C.L. Cornick et al., “Identification of a novel agonist of peroxisome proliferator-activated receptors alpha and gamma…”
The ethyl acetate extract of the gum of the guggul tree, Commiphora mukul (guggulipid), is marketed for the treatment of dyslipidaemia and obesity. We have found that it protects Lep(ob)/Lep(ob) mice from diabetes and have investigated possible molecular mechanisms for its metabolic effects, in particular those due to a newly identified component, commipheric acid. Read more >
- Clore Laboratory
- 14 September 2009
Claire Stocker (ed.), Type 2 Diabetes: Methods and Protocols
Diabetes is now reaching epidemic proportions, and the associated complications of this disease can be disabling and even life-threatening. In Type 2 Diabetes: Methods and Protocols, leading investigators provide up-to-date explanations of commonly used laboratory protocols used in diabetes research. Read more >