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Clore Laboratory: News
Diabetes, Obesity and Metabolic Research
24 May 2005 - Study of β-adrenoceptor agonist-mediated glucose uptake in muscle reported at BPS meeting on cell signalling
A poster on the role of Gs and Gi proteins in β-adrenoceptor agonist-mediated glucose uptake in muscle was presented by Robert Ngala, Clore Laboratory, University of Buckingham, UK, at the 4th Focused Meeting of the British Pharmacological Society, held 11–12 April 2005, University of Leicester, UK. The meeting was on Cell Signalling.
Robert’s poster addressed the involvement of Gs and Gi proteins, and phosphatidylinositol-3-kinase (PI3K), in β-adrenoceptor agonist-stimulated glucose uptake in soleus muscle.
The work indicates roles for both cyclic AMP and PI3K in glucose uptake stimulated by the β2 -adrenoceptor agonist clenbuterol, but neither pathway seems to play a role in responses to the β3 -adrenoceptor agonist BRL-37344. An intriguing finding was that pertussis toxin prevented clenbuterol from raising the cyclic AMP concentration and stimulating glucose uptake. In most systems pertussis toxin raises the cyclic AMP concentration by inhibiting the Gi protein.
The authors and title of the poster, the abstract of which will be published in pA2 online of the British Pharmacological Society, are:
Ngala RA, Wang SJY, Stocker C, Cawthorne MA, Arch JRS. Involvement of Gs and Gi proteins and phosphatidylinositol 3-kinase in clenbuterol- and BRL-37344-stimulated glucose uptake in soleus muscle