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Clore Laboratory: News
Diabetes, Obesity and Metabolic Research
17 October 2005 – Energy balance in DGAT-1 knockout mice studies presented at NAASO meeting
Jon Arch presented a poster on energy balance and glucose homeostasis in DGAT knockout mice at the Annual Scientific Meeting of NAASO, The Obesity Society, held in Vancouver, British Columbia, Canada, on 15–19 October 2005.
Body fat and plasma leptin were reduced in homozygous mice fed on a high fat diet, particularly in females. Heterozygous females had intermediate weight gain and fat content. Fasting glucose and insulin were reduced in knockout mice on a high fat diet and glucose tolerance was improved. There was no effect in heterozygotes.
The authors of the poster are Steven Wang, Claire Cornick, Jacqueline O’Dowd and Jonathan Arch.
The full reference to the abstract is:
Wang S, Cornick C, O’Dowd J, Arch J. Energy balance and glucose homeostasis in DGAT-1 homozygous and heterozygous knockout mice on chow and high fat diets. Obes Res 2005 13(Suppl 1): A52, 202-P