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Clore Laboratory: News
Diabetes, Obesity and Metabolic Research
12 January 2005 - Contrasting effects on insulin sensitivity of conjugated linoleic acid after short term and long term treatment
Results of a collaborative study by the Clore Laboratory, University of Buckingham, UK, Loders Croklaan BV, Wormerveer, The Netherlands, and Unilever Research, Sharnbrook, UK, are published in Lipids in Health and Disease .
Conjugated linoleic acid (CLA), especially its trans-10,cis-12 isomer, reduced body fat content, but some studies in man have shown that CLA promotes insulin resistance. In the current studies in a mouse model of obesity and insulin resistance it has been shown that prolonged treatment with CLA initially impairs insulin sensitivity further, but later beneficial effects on insulin sensitivity and glycaemic control were found, despite a dramatic reduction in plasma adiponectin concentration.
In vitro studies showed that the trans-10,cis-12 isomer but not the cis-9,trans-11 isomer stimulated PPARgamma-mediated reporter gene activity. Both isomers stimulated PPARalpha-mediated reporter gene activity.
The full author list and reference is:
Wargent E, Sennitt MV, Stocker C, Mayes AE, Brown L, O’Dowd J, Wang SJY, Einerhand AWC, Mohede I, Arch JRS, Cawthorne MA. Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation. Lipids Health Dis. 2005 Jan 10; 4: 3. doi:10.1186/1476-511X-4-3
The article can be downloaded from PubMed Central and http://www.lipidworld.com/content/4/1/3.